Nitric oxide
124 sourcesRay Peat was critical of the popular promotion of nitric oxide (NO) as beneficial. While NO was named 'Molecule of the Year' in 1992 for its vasodilatory effects, Peat documented extensive evidence that NO inhibits mitochondrial respiration (specifically cytochrome c oxidase), promotes inflammation, contributes to tissue damage, and combines with superoxide to form the highly destructive peroxynitrite. He viewed the promotion of NO-boosting supplements as another case of pharmaceutical marketing masquerading as science.
Peat noted that the vasodilation from NO comes at the cost of reduced cellular energy production, and that healthier vasodilation can be achieved through CO2, magnesium, and thyroid optimization without the mitochondrial damage.
Key Positions
- Nitric oxide inhibits cytochrome c oxidase, suppressing mitochondrial respiration
- NO combines with superoxide to form peroxynitrite, a powerful oxidant
- Vasodilation from NO comes at the cost of reduced cellular energy
- CO2 provides vasodilation without inhibiting mitochondrial respiration
- Magnesium promotes vascular relaxation through safer mechanisms than NO
- Excessive NO contributes to septic shock, neurodegeneration, and inflammation
- NO-boosting supplements may do more harm than good
Sources
124 items-
I Choose Ice Cream - Geneviève
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Immunodeficiency, dioxins, stress, and the hormones.
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Lactate vs. CO2 in wounds, sickness, and aging; the other approach to cancer
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Leakiness, aging, and cancer.
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Meat physiology, stress, and degenerative physiology
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Milk in context: allergies, ecology, and some myths
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Mitochondria and mortality
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Multiple sclerosis, protein, fats, and progesterone
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Peatarian Email Depository
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Preventing and treating cancer with progesterone.
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Progesterone, not estrogen, is the coronary protection factor of women.
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RU486, Cancer, Estrogen, and Progesterone
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Rosacea, inflammation, and aging: The inefficiency of stress
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Stem cells, cell culture, and culture: Issues in regeneration
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Sugar issues
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Suitable Fats, Unsuitable Fats: Issues in Nutrition
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The Cancer Matrix
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The dark side of stress (learned helplesness)
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Thyroid, insomnia, and the insanities: Commonalities in disease
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Unsaturated fatty acids: Nutritionally essential, or toxic?
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Vashinvetala (formerly Pranarupa)
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Vitamin E: Estrogen antagonist, energy promoter, and anti-inflammatory
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Water: swelling, tension, pain, fatigue, aging
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When energy fails: Edema, heart failure, hypertension, sarcopenia, etc.