Peat Archive

Ray Peat viewed allergies as manifestations of the broader inflammatory, estrogenic state rather than as isolated immune dysfunction. He noted that allergies involve histamine, serotonin, and prostaglandins — all of which are promoted by estrogen, PUFAs, and endotoxin. He argued that addressing the underlying metabolic and hormonal imbalances is more effective than merely treating symptoms.

Peat recommended thyroid optimization (hypothyroidism promotes allergies), reducing PUFAs (which provide the substrate for inflammatory mediators), supporting progesterone (which opposes estrogen and histamine), and using antihistamines strategically. He noted that many food sensitivities resolve when thyroid function and gut health improve.