Dhea
109 sourcesDHEA (dehydroepiandrosterone) is a protective steroid hormone that declines sharply with age — one of the most reliable biomarkers of aging. Ray Peat noted that DHEA opposes cortisol, supports immune function, protects the brain, and has anti-cancer properties. He viewed the DHEA-to-cortisol ratio as an important indicator of the body's stress status.
Peat recommended DHEA supplementation for older individuals, typically 5-15mg for women and 10-25mg for men, noting that it is converted to both androgens and estrogens in tissues. He emphasized that DHEA works best in the context of adequate thyroid function and progesterone, and that supplementing DHEA without addressing these can lead to imbalances.
Key Positions
- DHEA declines sharply with age — one of the most reliable aging biomarkers
- Opposes cortisol's catabolic effects on tissues
- Supports immune function and has anti-cancer properties
- The DHEA/cortisol ratio indicates overall stress and aging status
- Supplemental doses: 5-15mg for women, 10-25mg for men
- Converted to androgens and estrogens in tissues — context dependent
- Works best alongside adequate thyroid and progesterone
Sources
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Butter Living Podcast: Fertility, Pregnancy, and Development
Ray Peat interview/radio show on Wed Feb 19 2020 from Butter Living Podcast -
One Radio Network: Menopause, Estrogen, Thyroid, Coronavirus, and Glaucoma
Ray Peat interview/radio show on Mon Feb 17 2020 from One Radio Network -
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One Radio Network: Oxygen Saturation, Lactic Acid, Thyroid, Vaccines, PUFAs
Ray Peat interview/radio show on Mon Jan 20 2020 from One Radio Network -
Ask the Herb Doctor: Vibrations/Frequencies
Ray Peat interview/radio show on Fri Jan 17 2020 from Ask the Herb Doctor -
One Radio Network: Progesterone, estrogen, strokes, milk, sugars
Ray Peat interview/radio show on Tue Nov 19 2019 from One Radio Network -
Ask the Herb Doctor: Tryptophan
Ray Peat interview/radio show on Fri Nov 15 2019 from Ask the Herb Doctor -
One Radio Network: A Plethora of Wide-Randing Questions
Ray Peat interview/radio show on Tue Oct 15 2019 from One Radio Network -
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One Radio Network: Milk
Ray Peat interview/radio show on Thu Jul 18 2019 from One Radio Network -
Ask the Herb Doctor: Postpartum Depression
Ray Peat interview/radio show on Fri Jun 21 2019 from Ask the Herb Doctor -
Jodellefit: Cortisol, Low Testosterone
Ray Peat interview/radio show on Sat Jun 01 2019 from Jodellefit -
One Radio Network: The Goods
Ray Peat interview/radio show on Tue May 21 2019 from One Radio Network -
One Radio Network: Natural Healing
Ray Peat interview/radio show on Mon Apr 29 2019 from One Radio Network